Hiroshi Masutani Selected Research

Reye Syndrome (Reye's Syndrome)

10/2009	Thioredoxin-binding protein-2 deficiency enhances methionine-choline deficient diet-induced hepatic steatosis but inhibits steatohepatitis in mice.
9/2007	Thioredoxin and thioredoxin-binding protein-2 in cancer and metabolic syndrome.
1/2006	Impaired fatty acid utilization in thioredoxin binding protein-2 (TBP-2)-deficient mice: a unique animal model of Reye syndrome.

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Hiroshi Masutani Research Topics

Disease

14	Neoplasms (Cancer) 01/2022 - 03/2002
4	Carcinogenesis 01/2012 - 01/2002
3	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 01/2020 - 02/2004
3	Ischemia 09/2017 - 05/2009
3	Hypoglycemia (Reactive Hypoglycemia) 12/2010 - 03/2009
3	Reye Syndrome (Reye's Syndrome) 10/2009 - 01/2006
2	Infections 09/2017 - 01/2013
2	Hypoxia (Hypoxemia) 09/2017 - 01/2017
2	Inflammation (Inflammations) 09/2017 - 04/2016
2	Acute Lung Injury 04/2016 - 01/2013
2	Ulcer 01/2014 - 05/2002
2	Insulin Resistance 01/2012 - 11/2010
2	Type 2 Diabetes Mellitus (MODY) 01/2012 - 11/2010
2	Hemorrhage 10/2009 - 01/2006
2	Hepatitis 10/2009 - 10/2008
2	Neuroblastoma 12/2007 - 07/2003
2	Renal Cell Carcinoma (Grawitz Tumor) 12/2007 - 06/2005
2	Dehydration (Water Stress) 12/2003 - 07/2003
2	Cardiotoxicity 12/2003 - 09/2002
1	Thyroid Neoplasms (Thyroid Cancer) 01/2020
1	Chronic Obstructive Pulmonary Disease (COPD) 04/2016
1	Dermatitis 04/2016
1	Viral Pneumonia 04/2016
1	Virus Diseases (Viral Diseases) 04/2016
1	Lymphoma (Lymphomas) 01/2016
1	Burkitt Lymphoma (Burkitt's Lymphoma) 01/2016
1	Hodgkin Disease (Hodgkin's Disease) 01/2016
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 06/2015
1	Stomach Ulcer (Gastric Ulcer) 01/2014
1	Pneumonia (Pneumonitis) 01/2013
1	Human Influenza (Influenza) 01/2013
1	Diabetes Mellitus 01/2012
1	Urinary Bladder Neoplasms (Bladder Cancer) 10/2011
1	Insulinoma 07/2011
1	Wounds and Injuries (Trauma) 12/2010
1	Endotoxemia 12/2010
1	Hyperinsulinism (Hyperinsulinemia) 12/2010
1	Glucose Intolerance 11/2010
1	Obesity 11/2010
1	Fatty Liver 10/2009
1	Hyperlipidemias (Hyperlipidemia) 10/2009
1	Fibrosis (Cirrhosis) 10/2009
1	Hypertriglyceridemia 03/2009
1	Adenocarcinoma 12/2008

Drug/Important Bio-Agent (IBA)

20	ThioredoxinsIBA 01/2022 - 06/2002
14	Proteins (Proteins, Gene)FDA Link 01/2022 - 08/2002
10	tributyl phosphate (TBP)IBA 01/2012 - 03/2002
9	human TXNIP proteinIBA 01/2012 - 09/2004
5	Carrier Proteins (Binding Protein)IBA 01/2017 - 02/2004
4	Glucose (Dextrose)FDA LinkGeneric 01/2012 - 10/2009
3	CytokinesIBA 04/2016 - 10/2009
3	Pharmaceutical PreparationsIBA 09/2004 - 05/2002
2	ArrestinIBA 01/2022 - 01/2012
2	CaspasesIBA 01/2016 - 06/2002
2	Cysteine (L-Cysteine)FDA Link 06/2015 - 06/2002
2	Ethanol (Ethyl Alcohol)IBA 01/2014 - 07/2007
2	Insulin (Novolin)FDA Link 10/2011 - 12/2010
2	LipidsIBA 12/2010 - 09/2007
2	Fatty Acids (Saturated Fatty Acids)IBA 12/2010 - 01/2006
2	ferric nitrilotriacetateIBA 12/2007 - 06/2005
2	Cholecalciferol (Vitamin D3)FDA Link 09/2004 - 02/2004
2	ProstaglandinsIBA 12/2003 - 07/2003
2	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 12/2003 - 07/2003
2	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2003 - 09/2002
1	Interleukin-2 Receptors (IL 2 Receptor)IBA 01/2020
1	dithiolIBA 09/2017
1	cysteinylglycine (Cys-Gly)IBA 09/2017
1	Messenger RNA (mRNA)IBA 01/2017
1	Anti-Allergic Agents (Antiallergic Agents)IBA 04/2016
1	ChemokinesIBA 04/2016
1	Indomethacin (Indometacin)FDA LinkGeneric 04/2016
1	Antineoplastic Agents (Antineoplastics)IBA 04/2016
1	Monoclonal AntibodiesIBA 01/2016
1	Complement System Proteins (Complement)IBA 01/2016
1	Superoxide Dismutase-1IBA 06/2015
1	DNA (Deoxyribonucleic Acid)IBA 01/2014
1	Indicators and Reagents (Reagents)IBA 01/2012
1	Transforming Growth Factor beta (TGF-beta)IBA 01/2012
1	CXC ChemokinesIBA 10/2011
1	Epidermal Growth Factor (EGF)IBA 10/2011
1	NitrosaminesIBA 10/2011
1	4- fluorobenzoyl- Arg- Arg- Nal- Cys- Tyr- Cit- Lys- Lys- Pro- Tyr- Arg- Cit- Cys- Arg- NH2 (S-S bridged)IBA 10/2011
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 10/2011
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 07/2011
1	Triglycerides (Triacylglycerol)IBA 12/2010
1	GlycogenIBA 12/2010
1	CholesterolIBA 12/2010
1	EndotoxinsIBA 12/2010
1	Nonesterified Fatty Acids (NEFA)IBA 12/2010
1	LipopolysaccharidesIBA 12/2010
1	AdipokinesIBA 11/2010
1	Insulin Receptor Substrate ProteinsIBA 11/2010
1	Methionine (L-Methionine)FDA Link 10/2009
1	Choline (Choline Chloride)IBA 10/2009
1	Concanavalin AIBA 10/2009

Therapy/Procedure

2	Therapeutics 06/2007 - 06/2002
1	Skin Care 04/2016
1	Intravenous Injections 01/2016
1	Oral Administration 01/2014
1	Subcutaneous Injections 10/2011